Topical Antiandrogens

It is theorized that antiandrogens work by preventing Dihydrotestosterone from binding to the AR(androgen receptor). They tend to have a weak binding affinity to the AR compared with endogenous hormones and don't occupy the receptor for very long.

Cyoctol Administration

Cyoctol is a topical antiandrogen that prevents dihydrotestosterone from binding to its androgenic receptor. Also, after topical application, it is completely metabolized in the skin. In one study, a 0,05% solution topical cyoctol produced a modest increase in hair growth (11,3%).

As reported at the annual meeting of the American Academy of Dermatology in San Francisco. Dr.Richard Strick from UCLA, has been testing a new drug, cyoctol, for almost a year on 32 males, with an average 21% increase of hair growth in those who received the drug, compared to placebo^[1].

Spironolactone Administration

This aldosterone antagonist has a mild antiandrogenic effect. It is an inhibitor of ARP(androgen receptor proteins) binding. It also interferes with translocation of this complex into the cell nucleus. It also will deplete the Cytochrome P enzyme complex that weakly inhibits androgen biosynthesis in the adrenal glands.

References Cited

1. Gone today, hair tomorrow? (cyoctol as treatment for baldness) Publication: Medical Update (Newsletter) Date: January 1, 1990 Publisher: Benjamin Franklin Literary & Medical Society, Inc. Volume: v13 Issue: n7 Page: p2(1)